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Youth were considered to have used a GLP-1 if they were prescribed liraglutide (Saxenda, Novo Nordisk) or semaglutide (Wegovy, Novo Nordisk) within 12 months of an obesity diagnosis

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Patients with hepatic impairment generally do not require dose adjustment, as semaglutide is not extensively metabolized by the liver

Rev Endocr Metab Disord 15(3):181187 Shan Y, Tan S, Lin Y, Liao S, Zhang B, Chen X et al (2019) The glucagon-like peptide-1 receptor agonist reduces inflammation and blood-brain barrier breakdown in an astrocyte-dependent manner in experimental stroke