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Even changing the oral supplement to a sublingual tablet or lozenge has not been found to drastically change absorption rates (20, 21)

Naturally, B12 deficiency can lead to many health-related issues, the most common being weight gain

Methionine is then converted into S-adenosylmethionine (SAM), which donates methyl groups in reactions catalyzed by methyltransferases, including DNA methylation, producing S-adenosylhomocysteine (SAH) that is converted back into homocysteine