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12 Pfizer experienced three failures with its self-developed drugs in the GLP-1 field, including the termination of Lotiglipron development in June 2023 and the complete termination of Danuglipron development in April 2025

Barbour, MD, MSPH, FACP, professor in endocrinology, metabolism and diabetes and maternal-fetal medicine at University of Colorado

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Unlike GLP-1 receptor agonists, which directly activate the GLP-1 receptor and suppress appetite hormone signaling, natural alternatives work indirectlyenhancing metabolic function or supporting behavioral change