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I enlisted two Harvard colleagues, Ron Kahn and Bruce Spiegelman, and together we outlined an approach that included a search for novel insulin analogues and insulin sensitizing agents, identifying the protein responsible for obesity in genetically obese mice (six years before identification of the ob gene), and exploration of gut factors regulating metabolism, such as the incretins that enhanced insulin secretion

Then, acetyl-CoA is used directly for the generation of energy by the tricarboxylic acid cycle, or it can be converted to acetylcarnitine via the action of carnitine acetyltransferase for transport out of the mitochondria to be utilized elsewhere

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