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Molecular docking was conducted using AutoDock 4.2.3 by obtaining the 3D structure of the protein encoded by the key gene (in PDB format) and the structure of the candidate gut metabolite (in SDF format) for docking score calculation

Without enough glutathione to conjugate and clear the histamine, these inflammatory chemicals recirculate through the body, causing systemic MCAS symptoms like severe brain fog, hives, rapid heart rate (tachycardia), and profound digestive distress

Applications in the Exploration of Obesity Intervention Strategies and Drug Development Based on its unique mechanism of action and favorable physiological regulatory effects, NNMTi has become an important candidate molecule for the exploration of obesity intervention strategies and the development of antiobesity drugs

Most patients receive one intramuscular dose every three to four weeks, though the schedule may be shortened or extended based on symptom control and estradiol blood levels