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General Characteristics Peptide Type: Naturally occurring nonapeptide Sequence: TrpAlaGlyGlyAspAlaSerGlyGlu Form: Typically supplied as a lyophilized powder Solubility: Commonly reconstituted in sterile, researchgrade solvents Purity: Usually provided at high purity suitable for controlled laboratory research Storage & Handling Store in a cool, dry environment , protected from light Keep vial sealed until use Handle using standard laboratory safety procedures For laboratory research only

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RM-718 RM-718 is a cyclic heptapeptide developed by Rhythm Pharmaceuticals using setmelanotide as a template, with a focus on increasing MC4R potency and selectivity while limiting activity on MC1R to reduce skin pigmentation effects for once-weekly injection ( Figure 2 ) (130)