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Statements Author contributions JM wrote the paper with input from AV regarding content and layout

European neurology , 23 5, 372-85

Symptoms may include: Numbness, tingling, burning, or "wrong" sensations (parasthesias) anywhere in the body Gut motility disruption or enzyme secretion issues related to nervous system involvement Autonomic symptoms alongside peripheral pain or sensory changes Pain and fatigue patterns consistent with fibromyalgia, POTS, or connective tissue disorders The biopsy also tests for deposition of alpha-synuclein and amyloid - misfolded proteins that can reflect elevated total stress burden and are associated with Parkinson's and Alzheimer's disease respectively

With functional cDNA clones in hand and the ability to make unlimited quantities of infectious HCV RNA, much effort was devoted to searching for permissive HCV cell culture conditions