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Some patients may experience transient changes in blood pressure, though long-term cardiovascular outcomes studies have generally shown beneficial or neutral effects of GLP-1 receptor agonists on cardiovascular events

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NICE guidance on GLP-1 receptor agonists (NG28 for diabetes, TA875 for weight management) acknowledges these gastrointestinal effects and recommends that healthcare professionals counsel patients about expected side effects and management strategies before initiating treatment