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Some of the most common causes of kidney disease include: Diabetes (types 1 and 2) High blood pressure Glomerulonephritis (inflammation of the kidney's filtering units) Polycystic kidney disease (an inherited disorder causing fluid-filled cysts in the kidneys) Prolonged use of certain medications, such as NSAIDs Exposure to toxins and heavy metals In the early stages of kidney disease, you may not experience any symptoms