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Kisspeptin-10 Mitigates -Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner

After quality control (Qubit 4.0 and Tapestation) analysis, libraries were pooled together in equimolar concentrations and sequenced on two high-output runs in a single-end mode (186 bp) using a NextSeq500 Illumina sequencer (Illumina)

Within the hypothalamus, GLP-1 interacts with pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (it seems to have limited direct access here), a classic site involved in appetite regulation and energy expenditure

In preclinical models, chronic GLP-1 administration improves depression-like behaviors even in lean animals, an effect not mediated by weight loss