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They are not regulated as drugs and are not regulated as supplements

Furthermore, a randomized, double-blind, placebo-controlled trial in humans demonstrated that PYC supplementation markedly reduced the levels of key inflammatory biomarkers, including salivary MMP-8 and serum IL-6, supporting its anti-inflammatory effects (Braig et al., 2017

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While we understand the comment that MRFs may not be primarily intended for direct patient use, we disagree that they have little utility for patients and the public