semaglutide bone density (Ozempic) linked to fewer fractures despite greater weight loss A new study suggests semaglutide—the

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Those on tirzepatide at the highest dose lost closer to 21%

Preliminary data shows GLP-1 therapy doesnt lead to more lean mass loss than other weight-loss methods, especially when paired with exercise and nutrition support

In addition to its direct effects on beta cells, GIP also leads to increased glucagon secretion, and indirectly results in increased insulin secretion via communication between the alpha and beta cells of the pancreas ( via complex mechanisms, including stimulation of somatostatin secretion, which inhibits glucagon secretion, and indirectly via stimulation of insulin production, which then inhibits glucagon release ( Figure 1 Incretin action plays a large role on post-prandial secretion of insulin, and may account for up to 70% of hormone release ( Both incretins have effects outside the pancreas