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Limitations included the predominantly White and female participants, as well as normal baseline metabolic values, which may have attenuated the improvements

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Subsequent studies indicated that the two peptides (P11 and P12) with the stapling to i , i + 7 position derived from tryptophan 13 (Trp13) to Glu33 of autophagy related 16 like 1 gene (ATG16L1) showed high binding affinity to ATG5 ( K d = 36 nmol/L) compared to the control linear peptide (P13) with the K d of 0.072 mol/L, which could be partially given the credit to the stabilization of the helical by stapling [135]