However, genetics alone do not predict exact medication response or eliminate the need for careful TSH monitoring
Always start with the lowest dose and escalate gradually every four weeks
In contrast, limited weight loss or persistent appetite should prompt assessment of medication exposure, dose escalation, gastrointestinal tolerability, adherence, treatment interruption, concomitant medications, dietary compensation, and behavioural drivers of eating, consistent with evidence that early response may help identify patients more likely to achieve clinically meaningful longer-term weight loss (93)
People who are very physically active, such as athletes, may also notice leg cramps more often because of the way semaglutide affects the bodys electrolyte balance and hydration levels