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Considerations Before Starting Semaglutide: Before beginning treatment with semaglutide, patients should discuss their full medical history with their weight loss provider

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Despite the longer follow-up in STEP 5 (104 weeks versus 68 weeks in the other STEP trials), STEP 5 was again not designed or powered to assess the impact of semaglutide on the development of weight-related comorbidities such as cardiovascular disease

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