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These findings suggest the presence of epigenetic heterogeneity that may be driving the tumors aggressive biological behavior ( In this case, the patient developed an intracranial metastatic lesion following resection of the intradural MPNST, with imaging revealing a cystic-solid mass

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Among the targets of p53 activity are sestrins (sestrin 1 and 2) that induce the activity of peroxiredoxins, increasing the impact of the cellular antioxidant array 26