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In a controlled study cited in the same review, participants who slept 5.5 hours per night lost less fat and more fat-free mass than those who slept 8.5 hours per night. The authors reported that sleep curtailment decreased the proportion of weight lost as fat by 55% and increased the loss of fat-free body mass by 60%. Poor sleep has also been linked to increased hunger and changes in appetite-regulating hormones

JAMA Netw Open 2024;7:e2350408.ArticlePubMedPMC 63

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The drugs are contraindicated in pregnant women due to risk of developmental abnormalities in the foetus