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Signalling pathways studied in preclinical models illustrative Melanocyte Stimulation & Pigmentation MC1R Agonism Melanotan II (MTII) activates MC1R on melanocytes, stimulating intracellular cAMP production that drives melanogenesis the synthesis of eumelanin (brown-black) pigment

National Institute on Aging, "Exendin-4: From lizard to laboratory...and beyond" (2012)

Accumulation of SnCs during aging is due to the decrease of immune surveillance, probably related to dysregulation of pathways involved in the immune system activation 41,42

What are the risks of escalating the dose of tirzepatide (a dual GIP (Glucose-dependent Insulinotropic Polypeptide) and GLP-1 (Glucagon-like Peptide-1) receptor agonist) at week 3 instead of week 5?