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However, increases in circulating NAD precursors do not necessarily translate into proportional expansion of tissue-specific redox capacity, as precursor metabolism and systemic NAD pools are strongly influenced by microbial conversion and circulatory metabolism [109]

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Other adverse reactions include: Central Nervous System Drowsiness, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dysphoria, psychological dependence, mood changes