Proteccin renal con los agonistas del receptor del pptido similar al glucagn tipo 1 En los CVOT de los arGLP1 los resultados renales se preespecificaron como resultados secundarios clave en 4 estudios con liraglutida, semaglutida subcutnea, dulaglutida y efpeglenatida58,59,63,64, o se recogieron como parmetros de seguridad en otros estudios60
Timing can also play a role
Neurological Function Score (Modified Longa System) Neurological deficits were evaluated 1 hour after ET-1 injection using the modified Longa scoring system: 0: No observable neurological deficit (excluded from analysis) 1: Failure to fully extend the left forepaw 2: Consistent circling to the left 3: Falling or leaning to the left side when ambulating 4: No spontaneous movement (severe infarction) Animals scoring between 1 and 3 were considered to have moderate ischemic deficits and were included in further analyses
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