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In patients with herpesvirus CNS infections, bloodbrain barrier disruption can increase ACV concentrations, which may lead to acyclovir-induced neuropsychiatric symptoms (AINS) associated with high cerebrospinal fluid levels of the metabolite 9-carboxymethoxymethylguanine (CMMG) [57]
Relevant markers include malondialdehyde (MDA), 8-isoprostane, reduced glutathione (GSH), and high-sensitivity CRP
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In February 2026, the FDA restricted GLP-1 APIs in non-approved compounded products, tightening enforcement in one area while, at the same time, Kennedys announcement committed to loosening access across 14 others
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