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In one notable double-blind RCT published in the Journal of Clinical and Experimental Hepatology , 60 patients with NAFLD received either 600 mg of NAC twice daily or placebo for three months

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For intervention studies, the most informative designs will be those that pair such biomarkers with therapeutically timed treatment in human acinar, organoid, or ex vivo tissue platforms before progression to etiology-diverse in vivo models (96)