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The interaction between tirzepatide and levothyroxine is well-documented, predictable, and manageable with the right monitoring protocol

In addition to dietary intake, malabsorption conditions like celiac disease, atrophic gastritis, and inflammatory bowel diseases, all of autoimmune nature and frequently associated with autoimmune thyroid diseases, must be taken into account when vitamin B12 requirements are evaluated [97,98,99]

Endogenous hyperinsulinemia may cause weight gain and obesity [30], and treatment with insulin causes substantial weight gain, and may even increase cardiovascular risk [31]