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Insulin resistance directly adds to this scenario irrespective of changes in glucose levels, body weight, blood pressure and lipids [53]

Highmark Client Tip Sheet CAA Section 204 Reporting 2026 December 2025 Updates: Highmark Pharmacy Blast: Pharmacy Program Updates and Reminders GLP-1 Coverage Update: Enhanced anti-obesity policy now includes coverage for members with BMI 40 and high-risk conditions (sleep apnea, cardiovascular disease, or advanced MASH), reflecting expanded clinical evidence

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The SURMOUNT trials for tirzepatide showed average losses of up to 22.5% of body weight figures that were previously only achievable with bariatric surgery