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Regarding the cardiovascular outcomes, when examining other individual components of MACE, the analysis showed no significant differences between combination therapy and GLP-1RA monotherapy or SGLT-2i monotherapy in terms of cardiovascular mortality, non-fatal myocardial infarction, stroke, and all-cause mortality (Fig

Mechanism of Action S (GLP 1) binds and activates the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the gastrointestinal tract, the cardiovascular system, and the central nervous system