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Multiple freezing and thawing cycles can exacerbate that effect and lead to a cumulative impact on the generation and growth of subvisible and visible particulates

doi: 10.2217/mmt-2018-0003 4 HahnHMLeeKGChoiWCheongSHMyungKBHahnHJ

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At the end of the study, Group B had a significant increase in the ratio of Bacteroidetes (good bacteria) to Firmicutes (bad bacteria) in their system that went from 0.85 to 0.57