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SL played an important protective role in the early stage of acetaminophen-induced acute liver injury by decreasing the activity and expression CYP2E1, reducing the production of toxic metabolites, and alleviating liver injury (Yang et al., 2022)

In 2021, Kishimoto et al., in a double-blind, placebo-controlled clinical trial, evaluated the anti-inflammatory effects of curcuRouge for 4 weeks on systemic inflammation in adults over 60 years of age in Japan [62]

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It is primarily sold as a research chemical and is associated with safety risks, including inconsistent product quality and potential contamination due to lack of regulation