where was glp 1 discovered A timeline of GLP- discovery and clinical development. Created in Historical timeline of GLP-1 biology,

Copyright: 2020, American Society for Clinical Investigation

GLP-1R signaling regulates brain energy homeostasis and may improve mitochondrial function in depression In addition to the disturbed neuroimmune and neuroendocrine crosstalk, disruptions in brain metabolism and mitochondrial functions seem to be an emergent field of interest in the context of depression pathogenesis

Under the brand name Zepbound, it's approved to treat obesity, while under the brand name Mounjaro, it's approved to treat type 2 diabetes

Retatrutide can be administered via weekly subcutaneous injection due to its approximately six-day half-life