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Lastly, although many of the beneficial effects attributed to GLP-1 RAs are inferred from established molecular pathways or disease surrogates, it is essential to distinguish between weight-lossmediated and weight-independent geroscience effects

However, mood-related side effects like irritability, anxiety, or mood swings are not as clearly defined

New safety signal: dysesthesia (abnormal skin sensations) in up to 21% of participants on the highest dose

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