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We also identify a DNA binding interface in the C-terminal region of PDS5B and show that mutations of conserved basic amino acid residues in this region compromise the ability of PDS5B to stimulate RAD51 presynaptic filament assembly, RAD51-mediated DNA strand exchange, and protection of DNA against degradation by MRN

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Adverse effects can include nausea, vomiting, diarrhea, and bloating due to gastroparesis (tolerability)