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Companies like Noom and Hims have also launched programs to prescribe microdosed GLP-1s, claiming that these smaller doses can reduce metabolic risk, lower inflammatory markers, and even lower the risk of cognitive decline. Evidence of sustained patient use post-shortage: Prescription volume and utilization of compounded semaglutide and tirzepatide have continued to grow despite the end of medication shortages, suggesting that compounders may be leveraging additives or dosage adjustments to justify production

Maarbjerg and Jeanett Borregaard were employees of Novo Nordisk A/S at the time of conduct of the trial and preparation of this manuscript and are shareholders of Novo Nordisk A/S (current affiliation of SJM: Zealand Pharma A/S, Sborg, Denmark

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