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Though exact dosing for retatrutide in the weight-loss setting is still being defined (because many of the uses remain investigational), in the key trial adults with obesity treated weekly showed large body weight reductions: e.g., up to ~17.5% at 24 weeks and up to ~24% at 48 weeks in certain dose groups

By mimicking the natural GLP-1 hormone (but with a much longer half-life: 7 days vs minutes for natural GLP-1), Semaglutide produces sustained appetite suppression, improved insulin sensitivity, and reduced fasting blood glucose

Glucagon-like peptide (GLP)-1 receptor agonists are a key innovation in first-line treatments for type II diabetes