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An RDP multicenter study from 2008 showed that Pycnogenol supplementation significantly reduced abdominal discomfort in women with dysmenorrhea ( for two menstrual cycles, during which they needed significantly less analgesic medication than in the registration period of two months before supplementation (46%) and less than placebo controls (28%)

2.3 Diabetic retinopathy A neurovascular consequence of diabetes that can be prevented is diabetic retinopathy, which results in blindness [23]