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One such MSIA, termed IGF-1 MSIA-SRM, has been developed for IGF-1 with improved protocols for disrupting the IGF-1/IGFBP complex and for monitoring the immunoassays efficiency from sample preparation to mass spectrometric detection

It included: - Randomized controlled trials - Crossover studies - Open-label trials ...so the results are pretty robust

Others are marketed as research peptides or compounded formulations, but medical oversight is strongly recommended to ensure safety and appropriate dosing

Biochem J 430:439451 Lewerenz J, Ates G, Methner A, Conrad M, Maher P (2018) Oxytosis/ferroptosis-(Re-) emerging roles for oxidative stress-dependent non-apoptotic cell death in diseases of the central nervous system