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Although the presence of ascorbate in neurons is in part explained by its neuromodulatory enzyme activity, its high concentration suggests that vitamin C is so greatly retained by neurons in order to address the higher rates of oxidative metabolism experienced by the brain
One study reported that levels of l-carnitine in spinal fluid were lower in Alzheimer's patients without an APOE4 gene allele compared to patients with mild cognitive impairment [5]
After induction of hypertone, a strong positivity to Ub is detected (lane 3), which is significantly reduced in the retina concomitantly treated with carnitine (lane 2)
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