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While this study identifies an important function of epithelial cellexpressed protease beyond controlling digestive processes, we did not analyze all relevant proteases involved in PAR2-mediated homeostatic incretin regulation

Losing weight reduces this pressure and may lower the risk of developing hemorrhoids

Further, overexpression of metallothioneins, in response to increased inflammation of the olfactory epithelium may results in decreased zinc levels and subsequent loss of smell and taste (79)