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Rarely, metformin may cause potentially serious lactic acidosis, a buildup of lactic acid in the blood (Diabetes.co.uk 2016)

10.1517/14728222.2015.1077226 Summary Keywords oocyte, aneuploidy, embryo, endometriosis, infertility, reactive oxygen species, sperm Citation Mt G, Bernstein LR and Trk AL (2018) Endometriosis Is a Cause of Infertility

Supporting these findings, a recent PET (positron emission tomography) imaging study by (Kato et al., 2023) demonstrated a significant reduction in Complex I availability in the anterior cingulate cortex of ASD individuals, reinforcing the hypothesis that compromised mitochondrial respiration plays a key role in ASD pathophysiology