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It does cause some unwanted side effects, thoughmost notably gastrointestinal discomfort, such as nausea, diarrhea, and constipation

Providers may slow titration, hold a dose steady, or step back temporarily depending on symptoms and response

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While it has been studied over one to two years in clinical trials, there is limited data beyond that time frame, especially regarding: Long-term metabolic effects Nutrient deficiencies due to reduced food intake Potential changes to gut microbiota Dependency on the drug to maintain weight loss Potential changes to gut microbiota Some clinicians have voiced concern that stopping Ozempic can result in rapid weight regain and the return of previous metabolic issues