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PMID: 24217090

2.3 Study selection and data extraction After literature retrieval, two investigators (XX and CXF) independently screened the titles, abstracts, and full texts according to the inclusion and exclusion criteria

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Starting low and increasing under supervision gives the digestive system room to adjust to slowed gastric emptying and changing appetite cues, which is precisely why the sharpest side effects tend to cluster around each increase rather than at a steady dose