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Pfizer reported that its dose-optimization studies of once-daily formulations of danuglipron met key pharmacokinetic objectives and confirmed a formulation and dose with the potential to deliver a competitive efficacy and tolerability profile in Phase III testing, based on earlier studies of twice-daily danuglipron

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therefore, the authors of the study suggested that the MT-1 inhibition could be a therapeutic attractive target to restore and preserve insulin secretion in patients with T2DM [129]