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GLP-1RAs represent a promising new strategy for patients with psychiatric disorders, offering the possibility of meaningful weight loss while also improving metabolic health changes that can significantly enhance quality of life. They undertook a systematic review and meta-analysis of ultimately nine RCTs to assess the efficacy and safety of GLP-1 RAs in individuals with psychiatric disorders (specifically, schizophrenia or schizoaffective disorder, bipolar disorder, psychosis, major depressive disorder, binge-eating disorder, or a combination) and obesity/overweight, focusing on weight and metabolic outcomes