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Erythroblastic islands-associated tissue-resident ferritin-enriched macrophages perform a function of erythroblast nurse cells, supporting their survival and maturation, providing iron supply for hemoglobin synthesis, promoting proliferation via secreting erythropoiesis-enhancing factors such as IGF-1 and IL-18, and ensuring elimination of phosphatidylserine-exposing pyrenocytes, which represent the extruded nuclei formed within the enucleation process [47,48,49]