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Yes, semaglutide demonstrates consistent safety and efficacy in men across clinical trials and real-world use

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Cancer Risk Elevated levels of insulin-like growth factor-1 (IGF-1), which is the downstream effect of GH activity, have also raised theoretical concerns about an increased risk of cancer: According to Roberts, IGF-1 promotes cellular proliferation and inhibits apoptosis, two mechanisms that may contribute to the development of cancer cells in predisposed individuals (22)

The main characteristics of the studies selected for the pooled analysis are presented in Table 1