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Dark spots reduce significantly and skin texture improves Sessions 11 and beyond Deeper pigmentation continues to fade

31 AMX0114 Reduces Extracellular NfL Levels in Multiple Models of Trigger-Induced Neuronal Injury and Improves Survival in Relevant Models Pretreatment with AMX0114 Reduces Extracellular Pretreatment with AMX0114 improves motor neuron AMX0114 Treatment Improves Motor Neuron Survival in TDP43 ALS iPSC Model NfL in Vincristine Treated Neurons survival following oxidative stress (or H O exposure) 2 2 Representative Images of Motor Neurons TDP-43 ALS Model Pre- and Post-Exposure to H O 2 2 ALS model neurons Pre (0h) Post (144h) (no AMX0114) Healthy neurons Control (no AMX0114) ALS model neurons (with AMX0114) AMX0114 Bars represent mean (SD) Nfl concentrations relative to vehicle