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Am J Clin Nutr (1987) 46(1):8690

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In sepsis-induced AKI, the accumulation of lactic acid in renal tubules activates the programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) axis, leading to lymphocyte apoptosis and contributing to immunosuppression (Xu et al., 2021)

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The circulating half-life of endogenous amylin is short, with human studies indicating a half-life of 70% [108,109,110]

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