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Six enzymes of folic acid metabolism pathway were overexpressed, among which serine hydroxymethyltransferase 1 promoted the expression of cancer inflammatory factors by regulating sialic acid N-acetylneuraminic acid, and promoted the growth and metastasis of ovarian cancer tumor cells (69)

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Ethics declarations All procedures complied with the standards for care and use of animal subjects as stated in the Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Resources, National Academy of Sciences, Bethesda, MD)

In group II, the GPx deficit compared with the healthy individuals was 26.43%, with the mean values being decreased up to 73.57%