While one of the trials evaluated Orforglipron versus Dapagliflozin in 962 patients with type-2 diabetes inadequately controlled on Metformin, the other trial assessed Orforglipron versus placebo in 546 adults with type 2 diabetes and inadequate glycemic control with titrated insulin glargine
PLoS ONE 14 , e0212992 (2019)
Enzyme inactivation is not the only mechanism by which reactive electrophilic analogues of glutathione, such as EdAG, can elicit, disturb or disrupt biological mechanisms
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