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Human clinical-trial data (Phase 1/2 studies in wound healing, cardiac injury, and dry eye) exist only for a different, full-length recombinant thymosin beta-4 product, not for the short synthetic fragment marketed as TB-500, so no completed published human trial has evaluated TB-500 specifically for muscle, tendon, or joint recovery

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Gordon Holmes studies of cerebellar deficits in WWI veterans (1917) had firmly established the cerebellum as a key player in the coordination of movements, including eye movements [329]