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Contact your GP for persistent vomiting lasting more than 24 hours, signs of dehydration, nausea that does not improve after 46 weeks, or blood in vomit or stools

For patients with moderate renal insufficiency (CrCl greater than or equal to 30 to less than 50 mL/min, approximately corresponding to serum creatinine levels of greater than 1.7 to less than or equal to 3.0 mg/dL in men and greater than 1.5 to less than or equal to 2.5 mg/dL in women), the dose of Januvia is 50 mg once daily

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Draw the bacteriostatic water into a syringe, invert the Melanotan-1 vial, insert the needle through the rubber stopper at a shallow angle along the vial wall (not straight down into the powder), and allow the water to drip slowly down the glass rather than hitting the powder directly