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In contrast, we found that these metabolomic alterations led to a reduction in the plasma level of different metabolites including uridine, thymine, carnosine, theophylline, aspartate, taurine, serine, glutamate, tryptophan, arginine, and 53 other metabolites in the acute patients compared to HCs ( Supplementary Figures 6A, B )

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The trial focused on: Percentage of body weight lost Changes in blood sugar levels Shifts in blood pressure Tolerability at different doses, including the highest dose Safety over a longer treatment period This approach helped determine how the Eli Lilly weight-loss study compares to earlier GLP-1 research